9q8z

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Current revision (19:30, 4 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9q8z is ON HOLD until Paper Publication
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==Human chondroitin sulfate polymerase complex CHSY3-CHPF==
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<StructureSection load='9q8z' size='340' side='right'caption='[[9q8z]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9q8z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Q8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Q8Z FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9q8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9q8z OCA], [https://pdbe.org/9q8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9q8z RCSB], [https://www.ebi.ac.uk/pdbsum/9q8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9q8z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CHSS2_HUMAN CHSS2_HUMAN] Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Seems to act as a specific activating factor for CHSY1 in chondroitin polymerization (PubMed:12716890).<ref>PMID:12716890</ref> <ref>PMID:12761225</ref> May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, may enhance cell viability and protect cells from oxidative stress.<ref>PMID:22082830</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cordeiro RL]]
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[[Category: Dutta P]]
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[[Category: Wild R]]

Current revision

Human chondroitin sulfate polymerase complex CHSY3-CHPF

PDB ID 9q8z

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