13sp

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m (Protected "13sp" [edit=sysop:move=sysop])
Current revision (07:59, 11 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 13sp is ON HOLD
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==PanDDA analysis group deposition -- IDOL RING domain in complex with Z364577298==
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<StructureSection load='13sp' size='340' side='right'caption='[[13sp]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
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Authors: Bradshaw, W.J., Guenther, F., Murphy, E.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[13sp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=13SP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=13SP FirstGlance]. <br>
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Description: PanDDA analysis group deposition --IDOL RING domain in complex with Z364577298
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CYC:1-[(3S)-3-methylmorpholin-4-yl]-2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]ethan-1-one'>A1CYC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Bradshaw, W.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=13sp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=13sp OCA], [https://pdbe.org/13sp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=13sp RCSB], [https://www.ebi.ac.uk/pdbsum/13sp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=13sp ProSAT]</span></td></tr>
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[[Category: Murphy, E.J]]
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</table>
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[[Category: Guenther, F]]
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== Function ==
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[https://www.uniprot.org/uniprot/MYLIP_HUMAN MYLIP_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.<ref>PMID:10593918</ref> <ref>PMID:14550572</ref> <ref>PMID:12826659</ref> <ref>PMID:19520913</ref> <ref>PMID:20427281</ref> <ref>PMID:22109552</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bradshaw WJ]]
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[[Category: Guenther F]]
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[[Category: Murphy EJ]]

Current revision

PanDDA analysis group deposition -- IDOL RING domain in complex with Z364577298

PDB ID 13sp

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