13sq

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m (Protected "13sq" [edit=sysop:move=sysop])
Current revision (07:59, 11 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 13sq is ON HOLD
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==PanDDA analysis group deposition -- IDOL RING domain in complex with Z369936976==
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<StructureSection load='13sq' size='340' side='right'caption='[[13sq]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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Authors: Bradshaw, W.J., Guenther, F., Murphy, E.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[13sq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=13SQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=13SQ FirstGlance]. <br>
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Description: PanDDA analysis group deposition --IDOL RING domain in complex with Z369936976
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.301&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=U0P:N-cyclopropyl-N-methyl-N-[(5-methyl-1,2-oxazol-3-yl)methyl]urea'>U0P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Guenther, F]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=13sq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=13sq OCA], [https://pdbe.org/13sq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=13sq RCSB], [https://www.ebi.ac.uk/pdbsum/13sq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=13sq ProSAT]</span></td></tr>
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[[Category: Murphy, E.J]]
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</table>
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[[Category: Bradshaw, W.J]]
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== Function ==
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[https://www.uniprot.org/uniprot/MYLIP_HUMAN MYLIP_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.<ref>PMID:10593918</ref> <ref>PMID:14550572</ref> <ref>PMID:12826659</ref> <ref>PMID:19520913</ref> <ref>PMID:20427281</ref> <ref>PMID:22109552</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bradshaw WJ]]
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[[Category: Guenther F]]
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[[Category: Murphy EJ]]

Current revision

PanDDA analysis group deposition -- IDOL RING domain in complex with Z369936976

PDB ID 13sq

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