13ss

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m (Protected "13ss" [edit=sysop:move=sysop])
Current revision (07:59, 11 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 13ss is ON HOLD
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==PanDDA analysis group deposition -- IDOL RING domain in complex with Z57475877==
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<StructureSection load='13ss' size='340' side='right'caption='[[13ss]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
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Authors: Bradshaw, W.J., Guenther, F., Murphy, E.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[13ss]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=13SS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=13SS FirstGlance]. <br>
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Description: PanDDA analysis group deposition --IDOL RING domain in complex with Z57475877
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.689&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=S7S:~{N}-(2-ethyl-1,2,3,4-tetrazol-5-yl)butanamide'>S7S</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Bradshaw, W.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=13ss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=13ss OCA], [https://pdbe.org/13ss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=13ss RCSB], [https://www.ebi.ac.uk/pdbsum/13ss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=13ss ProSAT]</span></td></tr>
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[[Category: Murphy, E.J]]
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</table>
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[[Category: Guenther, F]]
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== Function ==
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[https://www.uniprot.org/uniprot/MYLIP_HUMAN MYLIP_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.<ref>PMID:10593918</ref> <ref>PMID:14550572</ref> <ref>PMID:12826659</ref> <ref>PMID:19520913</ref> <ref>PMID:20427281</ref> <ref>PMID:22109552</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bradshaw WJ]]
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[[Category: Guenther F]]
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[[Category: Murphy EJ]]

Current revision

PanDDA analysis group deposition -- IDOL RING domain in complex with Z57475877

PDB ID 13ss

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