9kxz

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Current revision (08:09, 11 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9kxz is ON HOLD until Paper Publication
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==Structure of human B0AT1-ACE2 complex with compound1==
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<StructureSection load='9kxz' size='340' side='right'caption='[[9kxz]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors: Imazu, T., Miyaguchi, I., Hiraizumi, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9kxz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KXZ FirstGlance]. <br>
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Description: Structure of human B0AT1-ACE2 complex with compound1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L6V:(~{E})-~{N}-[2-(dimethylamino)-2-oxidanylidene-ethyl]-3-[4-(trifluoromethyl)phenyl]prop-2-enamide'>A1L6V</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Miyaguchi, I]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kxz OCA], [https://pdbe.org/9kxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kxz RCSB], [https://www.ebi.ac.uk/pdbsum/9kxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kxz ProSAT]</span></td></tr>
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[[Category: Imazu, T]]
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</table>
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[[Category: Hiraizumi, M]]
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== Disease ==
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[https://www.uniprot.org/uniprot/S6A19_HUMAN S6A19_HUMAN] Hartnup disease;Iminoglycinuria. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry. SLC6A19 deficiency combined with haploinsufficiency of SLC6A20 or partially inactivating mutations in SLC36A2, can be responsible for hyperglycinuria. The disease may be caused by mutations affecting the gene represented in this entry. SLC6A19 deficiency combined with haploinsufficiency of SLC6A20 or partially inactivating mutations in SLC36A2, can be responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families.
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== Function ==
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[https://www.uniprot.org/uniprot/S6A19_HUMAN S6A19_HUMAN] Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:18424768, PubMed:18484095, PubMed:19185582, PubMed:26240152). This uptake is sodium-dependent and chloride-independent (PubMed:19185582, PubMed:15286788). Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:19185582, PubMed:18424768).<ref>PMID:15286788</ref> <ref>PMID:18424768</ref> <ref>PMID:18484095</ref> <ref>PMID:19185582</ref> <ref>PMID:26240152</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hiraizumi M]]
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[[Category: Imazu T]]
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[[Category: Miyaguchi I]]

Current revision

Structure of human B0AT1-ACE2 complex with compound1

PDB ID 9kxz

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