9ky0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:09, 11 December 2025) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 9ky0 is ON HOLD until Paper Publication
+
==Structure of human B0AT1-ACE2 complex with compound3==
-
 
+
<StructureSection load='9ky0' size='340' side='right'caption='[[9ky0]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
-
Authors: Imazu, T., Miyaguchi, I., Hiraizumi, M.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[9ky0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KY0 FirstGlance]. <br>
-
Description: Structure of human B0AT1-ACE2 complex with compound3
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L6W:(~{E})-~{N}-[2-oxidanylidene-2-(3-oxidanylidenepiperazin-1-yl)ethyl]-3-[4-(trifluoromethyl)phenyl]prop-2-enamide'>A1L6W</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
[[Category: Imazu, T]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ky0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ky0 OCA], [https://pdbe.org/9ky0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ky0 RCSB], [https://www.ebi.ac.uk/pdbsum/9ky0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ky0 ProSAT]</span></td></tr>
-
[[Category: Hiraizumi, M]]
+
</table>
-
[[Category: Miyaguchi, I]]
+
== Disease ==
 +
[https://www.uniprot.org/uniprot/S6A19_HUMAN S6A19_HUMAN] Hartnup disease;Iminoglycinuria. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry. SLC6A19 deficiency combined with haploinsufficiency of SLC6A20 or partially inactivating mutations in SLC36A2, can be responsible for hyperglycinuria. The disease may be caused by mutations affecting the gene represented in this entry. SLC6A19 deficiency combined with haploinsufficiency of SLC6A20 or partially inactivating mutations in SLC36A2, can be responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/S6A19_HUMAN S6A19_HUMAN] Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:18424768, PubMed:18484095, PubMed:19185582, PubMed:26240152). This uptake is sodium-dependent and chloride-independent (PubMed:19185582, PubMed:15286788). Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:19185582, PubMed:18424768).<ref>PMID:15286788</ref> <ref>PMID:18424768</ref> <ref>PMID:18484095</ref> <ref>PMID:19185582</ref> <ref>PMID:26240152</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Hiraizumi M]]
 +
[[Category: Imazu T]]
 +
[[Category: Miyaguchi I]]

Current revision

Structure of human B0AT1-ACE2 complex with compound3

PDB ID 9ky0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/9ky0"
Personal tools