9s1s

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Current revision (08:21, 11 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9s1s is ON HOLD until Paper Publication
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==Crystal structure of C278S mutant of mouse CDC14A in complex with a model phosphopeptide==
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<StructureSection load='9s1s' size='340' side='right'caption='[[9s1s]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
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Authors: Shabbir, K., Jackisch, G., Sele, C., Murina, V., Knecht, W., Wilson, E., Dong, L., Friedman, T.B., Imtiaz, A., Logan, D.T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9s1s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9S1S FirstGlance]. <br>
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Description: Crystal structure of C278S mutant of mouse CDC14A in complex with a model phosphopeptide
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Logan, D.T]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9s1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s1s OCA], [https://pdbe.org/9s1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s1s RCSB], [https://www.ebi.ac.uk/pdbsum/9s1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s1s ProSAT]</span></td></tr>
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[[Category: Knecht, W]]
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</table>
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[[Category: Jackisch, G]]
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== Function ==
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[[Category: Sele, C]]
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[https://www.uniprot.org/uniprot/CC14A_MOUSE CC14A_MOUSE] Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis (By similarity). Required for normal hearing (PubMed:29293958).[UniProtKB:Q9UNH5]<ref>PMID:29293958</ref>
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[[Category: Dong, L]]
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== References ==
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[[Category: Murina, V]]
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<references/>
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[[Category: Shabbir, K]]
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__TOC__
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[[Category: Imtiaz, A]]
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</StructureSection>
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[[Category: Friedman, T.B]]
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[[Category: Homo sapiens]]
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[[Category: Wilson, E]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Dong L]]
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[[Category: Friedman TB]]
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[[Category: Imtiaz A]]
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[[Category: Jackisch G]]
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[[Category: Knecht W]]
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[[Category: Logan DT]]
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[[Category: Murina V]]
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[[Category: Sele C]]
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[[Category: Shabbir K]]
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[[Category: Wilson E]]

Current revision

Crystal structure of C278S mutant of mouse CDC14A in complex with a model phosphopeptide

PDB ID 9s1s

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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