9z3q
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of KSHV glycoprotein gHgL in complex with MLKH3 and MLKH10 FABs== | |
| - | + | <StructureSection load='9z3q' size='340' side='right'caption='[[9z3q]], [[Resolution|resolution]] 3.51Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9z3q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Z3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Z3Q FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.51Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9z3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9z3q OCA], [https://pdbe.org/9z3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9z3q RCSB], [https://www.ebi.ac.uk/pdbsum/9z3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9z3q ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Lang | + | [https://www.uniprot.org/uniprot/GH_HHV8P GH_HHV8P] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity). Targets host EPHA2 to promote KSHV entry.[HAMAP-Rule:MF_04033]<ref>PMID:11932406</ref> <ref>PMID:22635007</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human gammaherpesvirus 8]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Aldridge N]] | ||
| + | [[Category: Lang K]] | ||
| + | [[Category: Pancera M]] | ||
Current revision
Cryo-EM structure of KSHV glycoprotein gHgL in complex with MLKH3 and MLKH10 FABs
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