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9t5s

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Current revision (13:11, 17 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9t5s is ON HOLD until Paper Publication
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==Crystal structure of human PPARalpha in complex with co-activator PGC-1 alpha peptide and bempedoic acid==
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<StructureSection load='9t5s' size='340' side='right'caption='[[9t5s]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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Authors: Useini, A., Strater, N., Kuenze, G., Heiker, J.T., Sheikh, B.N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9t5s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9T5S FirstGlance]. <br>
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Description: Crystal structure of human PPARalpha in complex with co-activator PGC-1 alpha peptide and bempedoic acid
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JTY:2,2,14,14-tetramethyl-8-oxidanyl-pentadecanedioic+acid'>A1JTY</scene></td></tr>
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[[Category: Useini, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9t5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t5s OCA], [https://pdbe.org/9t5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t5s RCSB], [https://www.ebi.ac.uk/pdbsum/9t5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t5s ProSAT]</span></td></tr>
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[[Category: Strater, N]]
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</table>
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[[Category: Heiker, J.T]]
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== Function ==
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[[Category: Sheikh, B.N]]
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[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
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[[Category: Kuenze, G]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Heiker JT]]
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[[Category: Kuenze G]]
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[[Category: Sheikh BN]]
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[[Category: Strater N]]
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[[Category: Useini A]]

Current revision

Crystal structure of human PPARalpha in complex with co-activator PGC-1 alpha peptide and bempedoic acid

PDB ID 9t5s

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OCA

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