Mevalonate kinase

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Current revision (09:02, 22 December 2025) (edit) (undo)
 
Line 29: Line 29:
[[1kkh]], [[1vis]] - MK - ''Methancaldococcus jannaschii''<br />
[[1kkh]], [[1vis]] - MK - ''Methancaldococcus jannaschii''<br />
[[8teb]] - MK - ''Methanococcoides burtonii''<br />
[[8teb]] - MK - ''Methanococcoides burtonii''<br />
-
[[8tfo]] - MK - ''Ramazzottius varieornatus''<br />
+
[[8tfo]] - MK + mevalonate - ''Ramazzottius varieornatus''<br />
[[2oi2]] - MK + diphosphomevalonate - ''Streptococcus pneumaniae''<br />
[[2oi2]] - MK + diphosphomevalonate - ''Streptococcus pneumaniae''<br />
[[2hfs]] - LmMK - ''Leishmania major''<br />
[[2hfs]] - LmMK - ''Leishmania major''<br />

Current revision

Mevalonate kinase complex with mevalonate (PDB code 2hfu).

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References

  1. Buhaescu I, Izzedine H. Mevalonate pathway: a review of clinical and therapeutical implications. Clin Biochem. 2007 Jun;40(9-10):575-84. doi: 10.1016/j.clinbiochem.2007.03.016., Epub 2007 Mar 31. PMID:17467679 doi:http://dx.doi.org/10.1016/j.clinbiochem.2007.03.016
  2. Levy M, Arion A, Berrebi D, Cuisset L, Jeanne-Pasquier C, Bader-Meunier B, Jung C. Severe early-onset colitis revealing mevalonate kinase deficiency. Pediatrics. 2013 Sep;132(3):e779-83. doi: 10.1542/peds.2012-3344. Epub 2013 Aug, 26. PMID:23979089 doi:http://dx.doi.org/10.1542/peds.2012-3344
  3. Sgraja T, Smith TK, Hunter WN. Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. BMC Struct Biol. 2007 Mar 30;7:20. PMID:17397541 doi:10.1186/1472-6807-7-20

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Alexander Berchansky, Michal Harel

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