We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

9hq0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:12, 24 December 2025) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 9hq0 is ON HOLD until Paper Publication
+
==SARM1 TIR domain in complex with compound 7-ADPR==
-
 
+
<StructureSection load='9hq0' size='340' side='right'caption='[[9hq0]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[9hq0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HQ0 FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IW3:[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2~{R},3~{S},4~{R},5~{R})-5-[4-[(1~{S})-1-[[(3~{R})-4,4-bis(fluoranyl)oxolan-3-yl]carbamoyl-methyl-amino]ethyl]pyridin-1-ium-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+hydrogen+phosphate'>A1IW3</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hq0 OCA], [https://pdbe.org/9hq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hq0 RCSB], [https://www.ebi.ac.uk/pdbsum/9hq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hq0 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Aregger N]]
 +
[[Category: Benz J]]
 +
[[Category: Bilyard M]]
 +
[[Category: Bonardi C]]
 +
[[Category: Brigo A]]
 +
[[Category: Burger D]]
 +
[[Category: Caramenti P]]
 +
[[Category: Gasser C]]
 +
[[Category: Giroud M]]
 +
[[Category: Grether U]]
 +
[[Category: Haap W]]
 +
[[Category: Haider A]]
 +
[[Category: Hilbert M]]
 +
[[Category: Kalayil S]]
 +
[[Category: Keaney J]]
 +
[[Category: Kuhn B]]
 +
[[Category: Malnight-Alvarez A]]
 +
[[Category: Mani A]]
 +
[[Category: Mendel M]]
 +
[[Category: Pinard E]]
 +
[[Category: Plitzko I]]
 +
[[Category: Ritter M]]
 +
[[Category: Rombach D]]
 +
[[Category: Saal W]]
 +
[[Category: Schmid P]]
 +
[[Category: Sechet N]]
 +
[[Category: Steiner S]]
 +
[[Category: Topp A]]
 +
[[Category: Westwood P]]
 +
[[Category: Wittwer M]]
 +
[[Category: Zambaldo C]]

Current revision

SARM1 TIR domain in complex with compound 7-ADPR

PDB ID 9hq0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/9hq0"
Personal tools