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9hqh

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Current revision (05:13, 24 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9hqh is ON HOLD until Paper Publication
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==SARM1 TIR domain in complex with compound 28-ADPR==
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<StructureSection load='9hqh' size='340' side='right'caption='[[9hqh]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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Authors: Giroud, M., Kuhn, B., Steiner, S., Westwood, P., Mendel, M., Mani, A., Pinard, E., Haap, W., Grether, U., Caramenti, P., Rombach, D., Zambaldo, C., Ritter, M., Schmid, P., Gasser, C., Aregger, N., Sechet, N., Topp, A., Bilyard, M., Malnight-Alvarez, A., Plitzko, I., Hilbert, M., Kalayil, S., Burger, D., Bonardi, C., Saal, W., Haider, A., Wittwer, M., Brigo, A., Keaney, J., Benz, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9hqh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HQH FirstGlance]. <br>
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Description: SARM1 TIR domain in complex with compound 28-ADPR
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.988&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IWN:[[(3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2~{R},3~{S},4~{R},5~{R})-5-[4-[(1~{R})-1-[[(3~{R})-4,4-bis(fluoranyl)oxolan-3-yl]carbamoyl-methyl-amino]-2-phenoxy-ethyl]pyridin-1-ium-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+hydrogen+phosphate'>A1IWN</scene></td></tr>
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[[Category: Caramenti, P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hqh OCA], [https://pdbe.org/9hqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hqh RCSB], [https://www.ebi.ac.uk/pdbsum/9hqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hqh ProSAT]</span></td></tr>
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[[Category: Malnight-Alvarez, A]]
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</table>
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[[Category: Benz, J]]
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== Function ==
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[[Category: Mani, A]]
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[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>
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[[Category: Steiner, S]]
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== References ==
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[[Category: Gasser, C]]
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<references/>
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[[Category: Kuhn, B]]
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__TOC__
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[[Category: Schmid, P]]
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</StructureSection>
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[[Category: Topp, A]]
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[[Category: Homo sapiens]]
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[[Category: Westwood, P]]
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[[Category: Large Structures]]
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[[Category: Bonardi, C]]
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[[Category: Aregger N]]
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[[Category: Burger, D]]
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[[Category: Benz J]]
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[[Category: Haap, W]]
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[[Category: Bilyard M]]
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[[Category: Haider, A]]
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[[Category: Bonardi C]]
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[[Category: Ritter, M]]
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[[Category: Brigo A]]
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[[Category: Grether, U]]
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[[Category: Burger D]]
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[[Category: Mendel, M]]
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[[Category: Caramenti P]]
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[[Category: Pinard, E]]
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[[Category: Gasser C]]
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[[Category: Aregger, N]]
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[[Category: Giroud M]]
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[[Category: Zambaldo, C]]
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[[Category: Grether U]]
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[[Category: Brigo, A]]
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[[Category: Haap W]]
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[[Category: Saal, W]]
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[[Category: Haider A]]
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[[Category: Hilbert, M]]
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[[Category: Hilbert M]]
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[[Category: Wittwer, M]]
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[[Category: Kalayil S]]
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[[Category: Rombach, D]]
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[[Category: Keaney J]]
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[[Category: Sechet, N]]
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[[Category: Kuhn B]]
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[[Category: Keaney, J]]
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[[Category: Malnight-Alvarez A]]
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[[Category: Kalayil, S]]
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[[Category: Mani A]]
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[[Category: Giroud, M]]
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[[Category: Mendel M]]
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[[Category: Bilyard, M]]
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[[Category: Pinard E]]
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[[Category: Plitzko, I]]
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[[Category: Plitzko I]]
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[[Category: Ritter M]]
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[[Category: Rombach D]]
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[[Category: Saal W]]
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[[Category: Schmid P]]
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[[Category: Sechet N]]
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[[Category: Steiner S]]
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[[Category: Topp A]]
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[[Category: Westwood P]]
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[[Category: Wittwer M]]
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[[Category: Zambaldo C]]

Current revision

SARM1 TIR domain in complex with compound 28-ADPR

PDB ID 9hqh

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