9j5e
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Hir2_WD40 in complex with Hpc2_NHRD== | |
| - | + | <StructureSection load='9j5e' size='340' side='right'caption='[[9j5e]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9j5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9J5E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9j5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j5e OCA], [https://pdbe.org/9j5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j5e RCSB], [https://www.ebi.ac.uk/pdbsum/9j5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j5e ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HIR2_YEAST HIR2_YEAST] Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during the cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.<ref>PMID:10445029</ref> <ref>PMID:11937489</ref> <ref>PMID:12524332</ref> <ref>PMID:16264190</ref> <ref>PMID:16303565</ref> <ref>PMID:16449659</ref> <ref>PMID:8417331</ref> <ref>PMID:9001207</ref> <ref>PMID:9671488</ref> <ref>PMID:9671489</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
| + | [[Category: Lin C-L]] | ||
Current revision
Crystal structure of Hir2_WD40 in complex with Hpc2_NHRD
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