1x7b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1x7b.gif|left|200px]]
[[Image:1x7b.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1x7b |SIZE=350|CAPTION= <scene name='initialview01'>1x7b</scene>, resolution 2.30&Aring;
+
The line below this paragraph, containing "STRUCTURE_1x7b", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=041:2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL'>041</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= ESR2, NR3A2, ESTRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1x7b| PDB=1x7b | SCENE= }}
-
|RELATEDENTRY=[[1u3q|1U3Q]], [[1u3r|1U3R]], [[1u3s|1U3S]], [[1u9e|1U9E]], [[1x76|1X76]], [[1x78|1X78]], [[1x7j|1X7J]], [[1x7r|1X7R]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x7b OCA], [http://www.ebi.ac.uk/pdbsum/1x7b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1x7b RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041'''
'''CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041'''
Line 41: Line 38:
[[Category: Wolfrom, S.]]
[[Category: Wolfrom, S.]]
[[Category: Xu, Z B.]]
[[Category: Xu, Z B.]]
-
[[Category: agonist]]
+
[[Category: Agonist]]
-
[[Category: er]]
+
[[Category: Er]]
-
[[Category: er-beta]]
+
[[Category: Er-beta]]
-
[[Category: estrogen]]
+
[[Category: Estrogen]]
-
[[Category: estrogen receptor]]
+
[[Category: Estrogen receptor]]
-
[[Category: estrogen receptor beta]]
+
[[Category: Estrogen receptor beta]]
-
[[Category: nuclear receptor]]
+
[[Category: Nuclear receptor]]
-
[[Category: transcription factor]]
+
[[Category: Transcription factor]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:39:32 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:45:40 2008''
+

Revision as of 11:39, 3 May 2008

Image:1x7b.gif

Template:STRUCTURE 1x7b

CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041


Overview

We present the structure-based optimization of a series of estrogen receptor-beta (ERbeta) selective ligands. X-ray cocrystal structures of these ligands complexed to both ERalpha and ERbeta are described. We also discuss how molecular modeling was used to take advantage of subtle differences between the two binding cavities in order to optimize selectivity for ERbeta over ERalpha. Quantum chemical calculations are utilized to gain insight into the mechanism of selectivity enhancement. Despite only two relatively conservative residue substitutions in the ligand binding pocket, the most selective compounds have greater than 100-fold selectivity for ERbeta relative to ERalpha when measured using a competitive radioligand binding assay.

About this Structure

1X7B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of estrogen receptor-beta selective ligands., Manas ES, Unwalla RJ, Xu ZB, Malamas MS, Miller CP, Harris HA, Hsiao C, Akopian T, Hum WT, Malakian K, Wolfrom S, Bapat A, Bhat RA, Stahl ML, Somers WS, Alvarez JC, J Am Chem Soc. 2004 Nov 24;126(46):15106-19. PMID:15548008 Page seeded by OCA on Sat May 3 14:39:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1x7b"
Personal tools