9vxw

Structural highlights

Function

AQP11_HUMAN Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:24845055, PubMed:24918044, PubMed:31546170). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:31546170). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (By similarity). Plays a role in the proximal tubule function by regulating its endosomal acidification (By similarity). May play a role in postnatal kidney development (By similarity).[UniProtKB:Q8BHH1]^{[1] [2] [3]}

References

1. ↑ Madeira A, Fernández-Veledo S, Camps M, Zorzano A, Moura TF, Ceperuelo-Mallafré V, Vendrell J, Soveral G. Human aquaporin-11 is a water and glycerol channel and localizes in the vicinity of lipid droplets in human adipocytes. Obesity (Silver Spring). 2014 Sep;22(9):2010-7. PMID:24845055 doi:10.1002/oby.20792
2. ↑ Takahashi S, Muta K, Sonoda H, Kato A, Abdeen A, Ikeda M. The role of Cysteine 227 in subcellular localization, water permeability, and multimerization of aquaporin-11. FEBS Open Bio. 2014 Mar 18;4:315-20. PMID:24918044 doi:10.1016/j.fob.2014.03.005
3. ↑ Bestetti S, Galli M, Sorrentino I, Pinton P, Rimessi A, Sitia R, Medraño-Fernandez I. Human aquaporin-11 guarantees efficient transport of H(2)O(2) across the endoplasmic reticulum membrane. Redox Biol. 2020 Jan;28:101326. PMID:31546170 doi:10.1016/j.redox.2019.101326