2adc

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Revision as of 18:42, 12 November 2007

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Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA

Overview

The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA, binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the, solution structures of the four RNA binding domains (RBDs) of PTB, each, bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different, binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel, orientation of their bound RNAs. Thus, PTB will induce RNA looping when, bound to two separated pyrimidine tracts within the same RNA. This leads, to structural models for how PTB functions as an alternative-splicing, repressor.

About this Structure

2ADC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of PTB bound to RNA: specific binding and implications for splicing regulation., Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, Allain FH, Science. 2005 Sep 23;309(5743):2054-7. PMID:16179478

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