We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
9o5f
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of EgtUC binding domain double mutant I243P T274G bound to L-Ergothioneine from S. pneumoniae== | |
| - | + | <StructureSection load='9o5f' size='340' side='right'caption='[[9o5f]], [[Resolution|resolution]] 1.36Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9o5f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_D39 Streptococcus pneumoniae D39]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9O5F FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=LW8:trimethyl-[(2~{S})-1-oxidanyl-1-oxidanylidene-3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)propan-2-yl]azanium'>LW8</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9o5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o5f OCA], [https://pdbe.org/9o5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o5f RCSB], [https://www.ebi.ac.uk/pdbsum/9o5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o5f ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/EGTUB_STRP2 EGTUB_STRP2] Part of an ABC transporter complex EgtU required for the uptake of ergothioneine (EGT), a natural low-molecular weight (LMW) thiol antioxidant (PubMed:36481738). Responsible for the translocation of the substrate across the membrane (PubMed:36481738). Also contains a C-terminal periplasmic solute-binding domain (SBD) which binds to EGT with sub-micromolar affinity (PubMed:36481738). Binds L-hercynine about 10,000-fold less tightly than EGT (PubMed:36481738). Cannot bind the structurally similar compounds L-histidine, proline-betaine, choline, ectoine, carnitine or dimethylpropiothetin (PubMed:36481738).<ref>PMID:36481738</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptococcus pneumoniae D39]] | ||
| + | [[Category: Giedroc DP]] | ||
| + | [[Category: Gonzalez-Gutierrez G]] | ||
| + | [[Category: Legg KA]] | ||
Current revision
Crystal Structure of EgtUC binding domain double mutant I243P T274G bound to L-Ergothioneine from S. pneumoniae
| |||||||||||
