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9zos

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m (Protected "9zos" [edit=sysop:move=sysop])
Current revision (09:34, 14 January 2026) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9zos is ON HOLD
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==OXA-23-JDB/PQ-1-219, 20 min complex==
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<StructureSection load='9zos' size='340' side='right'caption='[[9zos]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors: Smith, C.A., Maggiolo, A.M., Vakulenko, S.B., Toth, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9zos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZOS FirstGlance]. <br>
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Description: OXA-23-JDB/PQ-1-219, 20 min complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C3I:(5~{S})-5-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-3-[[(3~{R})-2,3-dihydroazet-3-yl]sulfanyl]-5-methyl-pyrrole-2-carboxylic+acid'>A1C3I</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Smith, C.A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zos OCA], [https://pdbe.org/9zos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zos RCSB], [https://www.ebi.ac.uk/pdbsum/9zos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zos ProSAT]</span></td></tr>
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[[Category: Toth, M]]
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</table>
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[[Category: Vakulenko, S.B]]
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== Function ==
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[[Category: Maggiolo, A.M]]
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[https://www.uniprot.org/uniprot/BLO23_ACIBA BLO23_ACIBA] Class D beta-lactamase which confers resistance to the beta-lactam antibiotics, including ampicillin, and carbapenems such as imipenem and meropenem (PubMed:18725452, PubMed:20194701, PubMed:24012371, PubMed:30530607, PubMed:35420470). Acts via hydrolysis of the beta-lactam ring (PubMed:23877677, PubMed:24012371, PubMed:30530607, PubMed:35420470). Has penicillin-, cephalosporin- and carbapenem-hydrolyzing activities, but lacks ceftazidime-hydrolyzing activity (PubMed:23877677, PubMed:24012371, PubMed:30530607, PubMed:35420470).<ref>PMID:18725452</ref> <ref>PMID:20194701</ref> <ref>PMID:23877677</ref> <ref>PMID:24012371</ref> <ref>PMID:30530607</ref> <ref>PMID:35420470</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Acinetobacter baumannii]]
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[[Category: Large Structures]]
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[[Category: Maggiolo AM]]
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[[Category: Smith CA]]
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[[Category: Toth M]]
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[[Category: Vakulenko SB]]

Current revision

OXA-23-JDB/PQ-1-219, 20 min complex

PDB ID 9zos

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