1xbd

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[[Image:1xbd.jpg|left|200px]]
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{{Structure
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|PDB= 1xbd |SIZE=350|CAPTION= <scene name='initialview01'>1xbd</scene>
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The line below this paragraph, containing "STRUCTURE_1xbd", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8] </span>
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{{STRUCTURE_1xbd| PDB=1xbd | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xbd OCA], [http://www.ebi.ac.uk/pdbsum/1xbd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xbd RCSB]</span>
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'''INTERNAL XYLAN BINDING DOMAIN FROM CELLULOMONAS FIMI XYLANASE D, NMR, 5 STRUCTURES'''
'''INTERNAL XYLAN BINDING DOMAIN FROM CELLULOMONAS FIMI XYLANASE D, NMR, 5 STRUCTURES'''
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[[Category: Simpson, P J.]]
[[Category: Simpson, P J.]]
[[Category: Williamson, M P.]]
[[Category: Williamson, M P.]]
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[[Category: beta-sheet]]
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[[Category: Beta-sheet]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: xylan binding domain]]
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[[Category: Xylan binding domain]]
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[[Category: xylanase]]
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[[Category: Xylanase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:48:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:47:22 2008''
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Revision as of 11:48, 3 May 2008

Image:1xbd.jpg

Template:STRUCTURE 1xbd

INTERNAL XYLAN BINDING DOMAIN FROM CELLULOMONAS FIMI XYLANASE D, NMR, 5 STRUCTURES


Overview

BACKGROUND: Many enzymes that digest polysaccharides contain separate polysaccharide-binding domains. Structures have been previously determined for a number of cellulose-binding domains (CBDs) from cellulases. RESULTS: The family IIb xylan-binding domain 1 (XBD1) from Cellulomonas fimi xylanase D is shown to bind xylan but not cellulose. Its structure is similar to that of the homologous family IIa CBD from C. fimi Cex, consisting of two four-stranded beta sheets that form a twisted 'beta sandwich'. The xylan-binding site is a groove made from two tryptophan residues that stack against the faces of the sugar rings, plus several hydrogen-bonding polar residues. CONCLUSIONS: The biggest difference between the family IIa and IIb domains is that in the former the solvent-exposed tryptophan sidechains are coplanar, whereas in the latter they are perpendicular, forming a twisted binding site. The binding sites are therefore complementary to the secondary structures of the ligands cellulose and xylan. XBD1 and CexCBD represent a striking example of two proteins that have high sequence similarity but a different function.

About this Structure

1XBD is a Single protein structure of sequence from Cellulomonas fimi. Full crystallographic information is available from OCA.

Reference

A family IIb xylan-binding domain has a similar secondary structure to a homologous family IIa cellulose-binding domain but different ligand specificity., Simpson PJ, Bolam DN, Cooper A, Ciruela A, Hazlewood GP, Gilbert HJ, Williamson MP, Structure. 1999 Jul 15;7(7):853-64. PMID:10425686 Page seeded by OCA on Sat May 3 14:48:50 2008

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