1xd2

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[[Image:1xd2.gif|left|200px]]
[[Image:1xd2.gif|left|200px]]
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{{Structure
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|PDB= 1xd2 |SIZE=350|CAPTION= <scene name='initialview01'>1xd2</scene>, resolution 2.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1xd2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= HRAS, HRAS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), SOS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1xd2| PDB=1xd2 | SCENE= }}
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|RELATEDENTRY=[[1nvv|1NVV]], [[1nvu|1NVU]], [[1nvw|1NVW]], [[1nvx|1NVX]], [[1bkd|1BKD]], [[1xd4|1XD4]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd2 OCA], [http://www.ebi.ac.uk/pdbsum/1xd2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xd2 RCSB]</span>
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}}
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'''Crystal Structure of a ternary Ras:SOS:Ras*GDP complex'''
'''Crystal Structure of a ternary Ras:SOS:Ras*GDP complex'''
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[[Category: Sondermann, H.]]
[[Category: Sondermann, H.]]
[[Category: Yang, S S.]]
[[Category: Yang, S S.]]
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[[Category: ras-nucleotide exchange factor complex]]
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[[Category: Ras-nucleotide exchange factor complex]]
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[[Category: ras:sos complex]]
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[[Category: Ras:sos complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:52:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:47:55 2008''
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Revision as of 11:52, 3 May 2008

Image:1xd2.gif

Template:STRUCTURE 1xd2

Crystal Structure of a ternary Ras:SOS:Ras*GDP complex


Contents

Overview

The classical model for the activation of the nucleotide exchange factor Son of sevenless (SOS) involves its recruitment to the membrane, where it engages Ras. The recent discovery that Ras*GTP is an allosteric activator of SOS indicated that the regulation of SOS is more complex than originally envisaged. We now present crystallographic and biochemical analyses of a construct of SOS that contains the Dbl homology-pleckstrin homology (DH-PH) and catalytic domains and show that the DH-PH unit blocks the allosteric binding site for Ras and suppresses the activity of SOS. SOS is dependent on Ras binding to the allosteric site for both a lower level of activity, which is a result of Ras*GDP binding, and maximal activity, which requires Ras*GTP. The action of the DH-PH unit gates a reciprocal interaction between Ras and SOS, in which Ras converts SOS from low to high activity forms as Ras*GDP is converted to Ras*GTP by SOS.

Disease

Known disease associated with this structure: Fibromatosis, gingival OMIM:[182530], Noonan syndrome 4 OMIM:[182530]

About this Structure

1XD2 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural analysis of autoinhibition in the Ras activator Son of sevenless., Sondermann H, Soisson SM, Boykevisch S, Yang SS, Bar-Sagi D, Kuriyan J, Cell. 2004 Oct 29;119(3):393-405. PMID:15507210 Page seeded by OCA on Sat May 3 14:52:30 2008

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OCA

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