1xd4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1xd4.gif|left|200px]]
[[Image:1xd4.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1xd4 |SIZE=350|CAPTION= <scene name='initialview01'>1xd4</scene>, resolution 3.64&Aring;
+
The line below this paragraph, containing "STRUCTURE_1xd4", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= SOS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1xd4| PDB=1xd4 | SCENE= }}
-
|RELATEDENTRY=[[1nvv|1NVV]], [[1dbh|1DBH]], [[1bkd|1BKD]], [[1xd2|1XD2]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xd4 OCA], [http://www.ebi.ac.uk/pdbsum/1xd4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xd4 RCSB]</span>
+
-
}}
+
'''Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS)'''
'''Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS)'''
Line 34: Line 31:
[[Category: Sondermann, H.]]
[[Category: Sondermann, H.]]
[[Category: Yang, S S.]]
[[Category: Yang, S S.]]
-
[[Category: cdc25]]
+
[[Category: Cdc25]]
-
[[Category: dbl homology(dh)]]
+
[[Category: Nucleotide exchange factor]]
-
[[Category: nucleotide exchange factor]]
+
[[Category: Ra]]
-
[[Category: pleckstrin homology (ph)]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:52:35 2008''
-
[[Category: ra]]
+
-
[[Category: ras exchanger motif (rem)]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:47:57 2008''
+

Revision as of 11:52, 3 May 2008

Image:1xd4.gif

Template:STRUCTURE 1xd4

Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS)


Contents

Overview

The classical model for the activation of the nucleotide exchange factor Son of sevenless (SOS) involves its recruitment to the membrane, where it engages Ras. The recent discovery that Ras*GTP is an allosteric activator of SOS indicated that the regulation of SOS is more complex than originally envisaged. We now present crystallographic and biochemical analyses of a construct of SOS that contains the Dbl homology-pleckstrin homology (DH-PH) and catalytic domains and show that the DH-PH unit blocks the allosteric binding site for Ras and suppresses the activity of SOS. SOS is dependent on Ras binding to the allosteric site for both a lower level of activity, which is a result of Ras*GDP binding, and maximal activity, which requires Ras*GTP. The action of the DH-PH unit gates a reciprocal interaction between Ras and SOS, in which Ras converts SOS from low to high activity forms as Ras*GDP is converted to Ras*GTP by SOS.

Disease

Known disease associated with this structure: Fibromatosis, gingival OMIM:[182530], Noonan syndrome 4 OMIM:[182530]

About this Structure

1XD4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural analysis of autoinhibition in the Ras activator Son of sevenless., Sondermann H, Soisson SM, Boykevisch S, Yang SS, Bar-Sagi D, Kuriyan J, Cell. 2004 Oct 29;119(3):393-405. PMID:15507210 Page seeded by OCA on Sat May 3 14:52:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xd4"
Personal tools