1xda

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[[Image:1xda.gif|left|200px]]
[[Image:1xda.gif|left|200px]]
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{{Structure
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|PDB= 1xda |SIZE=350|CAPTION= <scene name='initialview01'>1xda</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1xda", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1xda| PDB=1xda | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xda OCA], [http://www.ebi.ac.uk/pdbsum/1xda PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xda RCSB]</span>
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}}
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'''STRUCTURE OF INSULIN'''
'''STRUCTURE OF INSULIN'''
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[[Category: Jonassen, I.]]
[[Category: Jonassen, I.]]
[[Category: Whittingham, J L.]]
[[Category: Whittingham, J L.]]
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[[Category: chemical activity]]
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[[Category: Chemical activity]]
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[[Category: diabetes]]
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[[Category: Diabetes]]
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[[Category: fatty acid]]
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[[Category: Fatty acid]]
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[[Category: glucose metabolism]]
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[[Category: Glucose metabolism]]
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[[Category: hormone]]
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[[Category: Hormone]]
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[[Category: insulin albumin]]
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[[Category: Insulin albumin]]
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[[Category: metabolic role]]
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[[Category: Metabolic role]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:53:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:48:02 2008''
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Revision as of 11:53, 3 May 2008

Image:1xda.gif

Template:STRUCTURE 1xda

STRUCTURE OF INSULIN


Overview

The fatty acid acylated insulin, Lys(B29)-tetradecanoyl, des-(B30) human insulin, has been crystallized and the structure determined by X-ray crystallography. The fatty acid substituent on residue B29 Lys binds reversibly to circulating albumin protein in vivo, and by this mechanism the hormone's action is prolonged. Crystals of the fatty acid insulin grow in space group R3, with two dimers in the asymmetric unit, and diffract to 1.8 A spacing. The structure has been solved by molecular replacement and refined using a maximum likelihood method. The crystal structure consists of R6 zinc insulin hexamers which contain phenol. The fatty acids can be seen bound between the hexamers, making specific interactions with the side chains of residue B1 Phe; however, the lysine side chains to which the fatty acids are covalently attached are mostly disordered. The mode of binding of the fatty acids appears to be determined by crystal packing, and whether or not they interact with the protein in this way in solution remains uncertain.

About this Structure

1XDA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a prolonged-acting insulin with albumin-binding properties., Whittingham JL, Havelund S, Jonassen I, Biochemistry. 1997 Mar 11;36(10):2826-31. PMID:9062110 Page seeded by OCA on Sat May 3 14:53:00 2008

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