1xdo

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[[Image:1xdo.gif|left|200px]]
[[Image:1xdo.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1xdo |SIZE=350|CAPTION= <scene name='initialview01'>1xdo</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1xdo", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyphosphate_kinase Polyphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.1 2.7.4.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ppk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_1xdo| PDB=1xdo | SCENE= }}
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|RELATEDENTRY=[[1xdp|1XDP]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xdo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xdo OCA], [http://www.ebi.ac.uk/pdbsum/1xdo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xdo RCSB]</span>
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}}
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'''Crystal Structure of Escherichia coli Polyphosphate Kinase'''
'''Crystal Structure of Escherichia coli Polyphosphate Kinase'''
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[[Category: Xu, W.]]
[[Category: Xu, W.]]
[[Category: Zhu, Y.]]
[[Category: Zhu, Y.]]
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[[Category: e coli polyphosphate kinase]]
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[[Category: E coli polyphosphate kinase]]
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[[Category: polyphosphate kinase]]
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[[Category: Polyphosphate kinase]]
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[[Category: ppk]]
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[[Category: Ppk]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:53:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:48:13 2008''
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Revision as of 11:53, 3 May 2008

Image:1xdo.gif

Template:STRUCTURE 1xdo

Crystal Structure of Escherichia coli Polyphosphate Kinase


Overview

Polyphosphate (polyP), a linear polymer of hundreds of orthophosphate residues, exists in all tested cells in nature, from pathogenic bacteria to mammals. In bacteria, polyP has a crucial role in stress responses and stationary-phase survival. Polyphosphate kinase (PPK) is the principal enzyme that catalyses the synthesis of polyP in bacteria. It has been shown that PPK is required for bacterial motility, biofilm formation and the production of virulence factors. PPK inhibitors may thus provide a unique therapeutic opportunity against antibiotic-resistant pathogens. Here, we report crystal structures of full-length Escherichia coli PPK and its complex with AMPPNP (beta-gamma-imidoadenosine 5-phosphate). PPK forms an interlocked dimer, with each 80 kDa monomer containing four structural domains. The PPK active site is located in a tunnel, which contains a unique ATP-binding pocket and may accommodate the translocation of synthesized polyP. The PPK structure has laid the foundation for understanding the initiation of polyP synthesis by PPK.

About this Structure

1XDO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis., Zhu Y, Huang W, Lee SS, Xu W, EMBO Rep. 2005 Jul;6(7):681-7. PMID:15947782 Page seeded by OCA on Sat May 3 14:53:49 2008

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