1xdx
From Proteopedia
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'''Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1''' | '''Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1''' | ||
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[[Category: Takebe, S.]] | [[Category: Takebe, S.]] | ||
[[Category: Wu, H.]] | [[Category: Wu, H.]] | ||
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| - | [[Category: | + | [[Category: Nmr solution structure]] |
| - | [[Category: | + | [[Category: Tctex1 dimer]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:54:18 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 11:54, 3 May 2008
Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1
Overview
Tctex1 is a light chain found in both cytoplasmic and flagellar dyneins and is involved in many fundamental cellular activities, including rhodopsin transport within photoreceptors, and may function in the non-Mendelian transmission of t haplotypes in mice. Here, we present the NMR solution structure for the Tctex1 dimer from Chlamydomonas axonemal inner dynein arm I1. Structural comparisons reveal a strong similarity with the LC8 dynein light chain dimer, including formation of a strand-switched beta sheet interface. Analysis of the Tctex1 structure enables the dynein intermediate chain binding site to be identified and suggests a mechanism by which cargo proteins might be attached to this microtubule motor complex. Comparison with the alternate dynein light chain rp3 reveals how the specificity of dynein-cargo interactions mediated by these dynein components is achieved. In addition, this structure provides insight into the consequences of the mutations found in the t haplotype forms of this protein.
About this Structure
1XDX is a Single protein structure of sequence from Chlamydomonas reinhardtii. Full crystallographic information is available from OCA.
Reference
Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions., Wu H, Maciejewski MW, Takebe S, King SM, Structure. 2005 Feb;13(2):213-23. PMID:15698565 Page seeded by OCA on Sat May 3 14:54:18 2008
