2ajl
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(New page: 200px<br /> <applet load="2ajl" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ajl, resolution 2.5Å" /> '''X-ray Structure of N...)
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Revision as of 18:45, 12 November 2007
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X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor
Overview
The discovery, SAR, and X-ray crystal structure of novel, biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines, as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.
About this Structure
2AJL is a Single protein structure of sequence from Homo sapiens with NAG and JNH as ligands. Active as Dipeptidyl-peptidase IV, with EC number 3.4.14.5 Full crystallographic information is available from OCA.
Reference
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors., Qiao L, Baumann CA, Crysler CS, Ninan NS, Abad MC, Spurlino JC, Desjarlais RL, Kervinen J, Neeper MP, Bayoumy SS, Williams R, Deckman IC, Dasgupta M, Reed RL, Huebert ND, Tomczuk BE, Moriarty KJ, Bioorg Med Chem Lett. 2006 Jan 1;16(1):123-8. Epub 2005 Oct 19. PMID:16236500
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