1xjj

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[[Image:1xjj.gif|left|200px]]
[[Image:1xjj.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1xjj |SIZE=350|CAPTION= <scene name='initialview01'>1xjj</scene>, resolution 1.86&Aring;
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The line below this paragraph, containing "STRUCTURE_1xjj", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DGT:2&#39;-DEOXYGUANOSINE-5&#39;-TRIPHOSPHATE'>DGT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= nrdj ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])
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-->
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|DOMAIN=
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{{STRUCTURE_1xjj| PDB=1xjj | SCENE= }}
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|RELATEDENTRY=[[1xje|1XJE]], [[1xjf|1XJF]], [[1xjg|1XJG]], [[1xjk|1XJK]], [[1xjm|1XJM]], [[1xjn|1XJN]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xjj OCA], [http://www.ebi.ac.uk/pdbsum/1xjj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xjj RCSB]</span>
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}}
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'''Structural mechanism of allosteric substrate specificity in a ribonucleotide reductase: dGTP complex'''
'''Structural mechanism of allosteric substrate specificity in a ribonucleotide reductase: dGTP complex'''
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[[Category: Reichard, P.]]
[[Category: Reichard, P.]]
[[Category: 10 alpha-beta barrel]]
[[Category: 10 alpha-beta barrel]]
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[[Category: allosteric regulation]]
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[[Category: Allosteric regulation]]
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[[Category: protein-nucleotide complex]]
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[[Category: Protein-nucleotide complex]]
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[[Category: ribonucleotide reductase]]
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[[Category: Ribonucleotide reductase]]
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[[Category: substrate specificity]]
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[[Category: Substrate specificity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:06:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:50:28 2008''
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Revision as of 12:06, 3 May 2008

Image:1xjj.gif

Template:STRUCTURE 1xjj

Structural mechanism of allosteric substrate specificity in a ribonucleotide reductase: dGTP complex


Overview

Ribonucleotide reductases (RNRs) catalyze the reduction of ribonucleotides into deoxyribonucleotides, which constitute the precursor pools used for DNA synthesis and repair. Imbalances in these pools increase mutational rates and are detrimental to the cell. Balanced precursor pools are maintained primarily through the regulation of the RNR substrate specificity. Here, the molecular mechanism of the allosteric substrate specificity regulation is revealed through the structures of a dimeric coenzyme B12-dependent RNR from Thermotoga maritima, both in complexes with four effector-substrate nucleotide pairs and in three complexes with only effector. The mechanism is based on the flexibility of loop 2, a key structural element, which forms a bridge between the specificity effector and substrate nucleotides. Substrate specificity is achieved as different effectors and their cognate substrates stabilize specific discrete loop 2 conformations. The mechanism of substrate specificity regulation is probably general for most class I and class II RNRs.

About this Structure

1XJJ is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase., Larsson KM, Jordan A, Eliasson R, Reichard P, Logan DT, Nordlund P, Nat Struct Mol Biol. 2004 Nov;11(11):1142-9. Epub 2004 Oct 10. PMID:15475969 Page seeded by OCA on Sat May 3 15:06:46 2008

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