1xju

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[[Image:1xju.gif|left|200px]]
[[Image:1xju.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1xju |SIZE=350|CAPTION= <scene name='initialview01'>1xju</scene>, resolution 1.070&Aring;
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The line below this paragraph, containing "STRUCTURE_1xju", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= 17, LYSA, LyZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10678 Enterobacteria phage P1])
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-->
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|DOMAIN=
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{{STRUCTURE_1xju| PDB=1xju | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xju OCA], [http://www.ebi.ac.uk/pdbsum/1xju PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xju RCSB]</span>
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}}
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'''Crystal structure of secreted inactive form of P1 phage endolysin Lyz'''
'''Crystal structure of secreted inactive form of P1 phage endolysin Lyz'''
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[[Category: Arockiasamy, A.]]
[[Category: Arockiasamy, A.]]
[[Category: Sacchettini, J C.]]
[[Category: Sacchettini, J C.]]
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[[Category: secreted inactive conformation]]
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[[Category: Secreted inactive conformation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:07:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:50:34 2008''
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Revision as of 12:07, 3 May 2008

Image:1xju.gif

Template:STRUCTURE 1xju

Crystal structure of secreted inactive form of P1 phage endolysin Lyz


Overview

The P1 lysozyme Lyz is secreted to the periplasm of Escherichia coli and accumulates in an inactive membrane-tethered form. Genetic and biochemical experiments show that, when released from the bilayer, Lyz is activated by an intramolecular thiol-disulfide isomerization, which requires a cysteine in its N-terminal SAR (signal-arrest-release) domain. Crystal structures confirm the alternative disulfide linkages in the two forms of Lyz and reveal dramatic conformational differences in the catalytic domain. Thus, the exported P1 endolysin is kept inactive by three levels of control-topological, conformational, and covalent-until its release from the membrane is triggered by the P1 holin.

About this Structure

1XJU is a Single protein structure of sequence from Enterobacteria phage p1. Full crystallographic information is available from OCA.

Reference

Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme., Xu M, Arulandu A, Struck DK, Swanson S, Sacchettini JC, Young R, Science. 2005 Jan 7;307(5706):113-7. PMID:15637279 Page seeded by OCA on Sat May 3 15:07:20 2008

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