1xjv

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[[Image:1xjv.gif|left|200px]]
[[Image:1xjv.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1xjv |SIZE=350|CAPTION= <scene name='initialview01'>1xjv</scene>, resolution 1.73&Aring;
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The line below this paragraph, containing "STRUCTURE_1xjv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= POT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1xjv| PDB=1xjv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xjv OCA], [http://www.ebi.ac.uk/pdbsum/1xjv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xjv RCSB]</span>
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}}
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'''Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)'''
'''Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)'''
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[[Category: Lei, M.]]
[[Category: Lei, M.]]
[[Category: Podell, E R.]]
[[Category: Podell, E R.]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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[[Category: single-stranded dna]]
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[[Category: Single-stranded dna]]
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[[Category: telomere]]
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[[Category: Telomere]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:07:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:50:35 2008''
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Revision as of 12:07, 3 May 2008

Image:1xjv.gif

Template:STRUCTURE 1xjv

Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)


Overview

The POT1 (protection of telomeres 1) protein binds the single-stranded overhang at the ends of chromosomes in diverse eukaryotes. It is essential for chromosome end-protection in the fission yeast Schizosaccharomyces pombe, and it is involved in regulation of telomere length in human cells. Here, we report the crystal structure at a resolution of 1.73 A of the N-terminal half of human POT1 (hPOT1) protein bound to a telomeric single-stranded DNA (ssDNA) decamer, TTAGGGTTAG, the minimum tight-binding sequence indicated by in vitro binding assays. The structure reveals that hPOT1 contains two oligonucleotide/ oligosaccharide-binding (OB) folds; the N-terminal OB fold binds the first six nucleotides, resembling the structure of the S. pombe Pot1pN-ssDNA complex, whereas the second OB fold binds and protects the 3' end of the ssDNA. These results provide an atomic-resolution model for chromosome end-capping.

About this Structure

1XJV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection., Lei M, Podell ER, Cech TR, Nat Struct Mol Biol. 2004 Dec;11(12):1223-9. Epub 2004 Nov 21. PMID:15558049 Page seeded by OCA on Sat May 3 15:07:22 2008

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