1xls

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1xls.gif|left|200px]]
[[Image:1xls.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1xls |SIZE=350|CAPTION= <scene name='initialview01'>1xls</scene>, resolution 2.96&Aring;
+
The line below this paragraph, containing "STRUCTURE_1xls", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene>, <scene name='pdbligand=TCD:3,5-DICHLORO-2-{4-[(3,5-DICHLOROPYRIDIN-2-YL)OXY]PHENOXY}PYRIDINE'>TCD</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), mouse ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1xls| PDB=1xls | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xls OCA], [http://www.ebi.ac.uk/pdbsum/1xls PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xls RCSB]</span>
+
-
}}
+
'''Crystal structure of the mouse CAR/RXR LBD heterodimer bound to TCPOBOP and 9cRA and a TIF2 peptide containg the third LXXLL motifs'''
'''Crystal structure of the mouse CAR/RXR LBD heterodimer bound to TCPOBOP and 9cRA and a TIF2 peptide containg the third LXXLL motifs'''
Line 33: Line 30:
[[Category: Suino, K.]]
[[Category: Suino, K.]]
[[Category: Xu, H E.]]
[[Category: Xu, H E.]]
-
[[Category: peng, L.]]
+
[[Category: Peng, L.]]
-
[[Category: car]]
+
[[Category: Car]]
-
[[Category: lbd]]
+
[[Category: Lbd]]
-
[[Category: nuclear receptor]]
+
[[Category: Nuclear receptor]]
-
[[Category: xenobiotic]]
+
[[Category: Xenobiotic]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:11:32 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:51:27 2008''
+

Revision as of 12:11, 3 May 2008

Image:1xls.gif

Template:STRUCTURE 1xls

Crystal structure of the mouse CAR/RXR LBD heterodimer bound to TCPOBOP and 9cRA and a TIF2 peptide containg the third LXXLL motifs


Overview

Constitutive androstane receptor (CAR) induces xenobiotic, bilirubin, and thyroid hormone metabolism as a heterodimer with the retinoid X receptor (RXR). Unlike ligand-dependent nuclear receptors, CAR is constitutively active. Here, we report the heterodimeric structure of the CAR and RXR ligand binding domains (LBDs), which reveals an unusually large dimerization interface and a small CAR ligand binding pocket. Constitutive CAR activity appears to be mediated by the compact nature of the CAR LBD that displays several unique features including a shortened AF2 helix and helix H10, which are linked by a two-turn helix that normally adopts an extended loop in other receptors, and an extended helix H2 that stabilizes the canonical LBD fold by packing tightly against helix H3. These structural observations provide a molecular framework for understanding the atypical transcriptional activation properties of CAR.

About this Structure

1XLS is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization., Suino K, Peng L, Reynolds R, Li Y, Cha JY, Repa JJ, Kliewer SA, Xu HE, Mol Cell. 2004 Dec 22;16(6):893-905. PMID:15610733 Page seeded by OCA on Sat May 3 15:11:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xls"
Personal tools