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1xm9

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[[Image:1xm9.gif|left|200px]]
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|GENE= PKP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xm9 OCA], [http://www.ebi.ac.uk/pdbsum/1xm9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xm9 RCSB]</span>
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'''Structure of the armadillo repeat domain of plakophilin 1'''
'''Structure of the armadillo repeat domain of plakophilin 1'''
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[[Category: Choi, H J.]]
[[Category: Choi, H J.]]
[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
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[[Category: armadillo repeat]]
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[[Category: Armadillo repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:12:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:51:35 2008''
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Revision as of 12:12, 3 May 2008

Image:1xm9.gif

Template:STRUCTURE 1xm9

Structure of the armadillo repeat domain of plakophilin 1


Contents

Overview

The p120ctn subfamily of armadillo domain proteins has roles in modulating intercellular adhesion by cadherin-containing junctions. We have determined the crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member of the p120ctn subfamily that is found in desmosomes. The structure reveals that the domain has nine instead of the expected ten arm repeats. A sequence predicted to be an arm repeat is instead a large insert which serves as a wedge that produces a significant bend in the overall domain structure. Structure-based sequence alignments indicate that the nine repeats and large insert are common to this subfamily of armadillo proteins. A prominent basic patch on the surface of the protein may serve as a binding site for partners of these proteins.

Disease

Known disease associated with this structure: Ectodermal dysplasia/skin fragility syndrome OMIM:[601975]

About this Structure

1XM9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the armadillo repeat domain of plakophilin 1., Choi HJ, Weis WI, J Mol Biol. 2005 Feb 11;346(1):367-76. Epub 2004 Dec 19. PMID:15663951 Page seeded by OCA on Sat May 3 15:12:49 2008

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