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1xoe

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[[Image:1xoe.gif|left|200px]]
[[Image:1xoe.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1xoe |SIZE=350|CAPTION= <scene name='initialview01'>1xoe</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1xoe", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ABX:5-[1-(ACETYLAMINO)-3-METHYLBUTYL]-4-(METHOXYCARBONYL)PROLINE'>ABX</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1xoe| PDB=1xoe | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xoe OCA], [http://www.ebi.ac.uk/pdbsum/1xoe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xoe RCSB]</span>
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}}
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'''N9 Tern influenza neuraminidase complexed with (2R,4R,5R)-5-(1-Acetylamino-3-methyl-butyl-pyrrolidine-2, 4-dicarobyxylic acid 4-methyl esterdase complexed with'''
'''N9 Tern influenza neuraminidase complexed with (2R,4R,5R)-5-(1-Acetylamino-3-methyl-butyl-pyrrolidine-2, 4-dicarobyxylic acid 4-methyl esterdase complexed with'''
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[[Category: Wang, G T.]]
[[Category: Wang, G T.]]
[[Category: Wang, S.]]
[[Category: Wang, S.]]
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[[Category: influenza]]
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[[Category: Influenza]]
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[[Category: neuraminidase]]
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[[Category: Neuraminidase]]
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[[Category: pyrrolidine inhibitor]]
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[[Category: Pyrrolidine inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:17:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:52:23 2008''
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Revision as of 12:17, 3 May 2008

Image:1xoe.gif

Template:STRUCTURE 1xoe

N9 Tern influenza neuraminidase complexed with (2R,4R,5R)-5-(1-Acetylamino-3-methyl-butyl-pyrrolidine-2, 4-dicarobyxylic acid 4-methyl esterdase complexed with


Overview

(+/-)-(2R,3R,5R)-[2-(1'-S-acetamido-3'-methyl)butyl-3-methoxycarbonyl]tetr ahydrofuran-5-carboxylic acid (9) and (+/-)-(2R,3R,5R)-[2-(1'-S-acetamido-3'-methyl)butyl-3-(4'-imidazolyl)]tetr ahydrofuran 5-carboxylic acid (14) were synthesized as inhibitors of influenza neuraminidase (NA). Both compounds 9 and 14 inhibit influenza NA A with an IC(50) of about 0.5 microM and NA B with an IC(50) of 1.0 microM.

About this Structure

1XOE is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.

Reference

Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core., Wang GT, Wang S, Gentles R, Sowin T, Maring CJ, Kempf DJ, Kati WM, Stoll V, Stewart KD, Laver G, Bioorg Med Chem Lett. 2005 Jan 3;15(1):125-8. PMID:15582424 Page seeded by OCA on Sat May 3 15:17:47 2008

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OCA

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