This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1xog

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1xog.gif|left|200px]]
[[Image:1xog.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1xog |SIZE=350|CAPTION= <scene name='initialview01'>1xog</scene>, resolution 2.80&Aring;
+
The line below this paragraph, containing "STRUCTURE_1xog", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ABW:5-[1-(ACETYLAMINO)-3-METHYLBUTYL]-2,5-ANHYDRO-3,4-DIDEOXY-4-(METHOXYCARBONYL)PENTONIC+ACID'>ABW</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1xog| PDB=1xog | SCENE= }}
-
|RELATEDENTRY=[[1xoe|1XOE]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xog OCA], [http://www.ebi.ac.uk/pdbsum/1xog PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xog RCSB]</span>
+
-
}}
+
'''N9 Tern Influenza neuraminidase complexed with a 2,5-Disubstituted tetrahydrofuran-5-carboxylic acid'''
'''N9 Tern Influenza neuraminidase complexed with a 2,5-Disubstituted tetrahydrofuran-5-carboxylic acid'''
Line 36: Line 33:
[[Category: Wang, G T.]]
[[Category: Wang, G T.]]
[[Category: Wang, S.]]
[[Category: Wang, S.]]
-
[[Category: influenza]]
+
[[Category: Influenza]]
-
[[Category: neuraminidase]]
+
[[Category: Neuraminidase]]
-
[[Category: tetrahydrofuran inhibitor]]
+
[[Category: Tetrahydrofuran inhibitor]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:17:51 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:52:25 2008''
+

Revision as of 12:17, 3 May 2008

Image:1xog.gif

Template:STRUCTURE 1xog

N9 Tern Influenza neuraminidase complexed with a 2,5-Disubstituted tetrahydrofuran-5-carboxylic acid


Overview

(+/-)-(2R,3R,5R)-[2-(1'-S-acetamido-3'-methyl)butyl-3-methoxycarbonyl]tetr ahydrofuran-5-carboxylic acid (9) and (+/-)-(2R,3R,5R)-[2-(1'-S-acetamido-3'-methyl)butyl-3-(4'-imidazolyl)]tetr ahydrofuran 5-carboxylic acid (14) were synthesized as inhibitors of influenza neuraminidase (NA). Both compounds 9 and 14 inhibit influenza NA A with an IC(50) of about 0.5 microM and NA B with an IC(50) of 1.0 microM.

About this Structure

1XOG is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.

Reference

Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core., Wang GT, Wang S, Gentles R, Sowin T, Maring CJ, Kempf DJ, Kati WM, Stoll V, Stewart KD, Laver G, Bioorg Med Chem Lett. 2005 Jan 3;15(1):125-8. PMID:15582424 Page seeded by OCA on Sat May 3 15:17:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xog"
Personal tools