1xok

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[[Image:1xok.gif|left|200px]]
[[Image:1xok.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1xok |SIZE=350|CAPTION= <scene name='initialview01'>1xok</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1xok", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1xok| PDB=1xok | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xok OCA], [http://www.ebi.ac.uk/pdbsum/1xok PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xok RCSB]</span>
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}}
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'''crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide'''
'''crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide'''
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==About this Structure==
==About this Structure==
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1XOK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOK OCA].
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1XOK is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOK OCA].
==Reference==
==Reference==
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[[Category: Guogas, L M.]]
[[Category: Guogas, L M.]]
[[Category: Hogle, J M.]]
[[Category: Hogle, J M.]]
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[[Category: alpha helix]]
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[[Category: Alpha helix]]
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[[Category: atypical rna duplex]]
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[[Category: Atypical rna duplex]]
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[[Category: protein-rna complex]]
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[[Category: Protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:17:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:52:27 2008''
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Revision as of 12:17, 3 May 2008

Image:1xok.gif

Template:STRUCTURE 1xok

crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide


Overview

Alfalfa mosaic virus genomic RNAs are infectious only when the viral coat protein binds to the RNA 3' termini. The crystal structure of an alfalfa mosaic virus RNA-peptide complex reveals that conserved AUGC repeats and Pro-Thr-x-Arg-Ser-x-x-Tyr coat protein amino acids cofold upon interacting. Alternating AUGC residues have opposite orientation, and they base pair in different adjacent duplexes. Localized RNA backbone reversals stabilized by arginine-guanine interactions place the adenosines and guanines in reverse order in the duplex. The results suggest that a uniform, organized 3' conformation, similar to that found on viral RNAs with transfer RNA-like ends, may be essential for replication.

About this Structure

1XOK is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication., Guogas LM, Filman DJ, Hogle JM, Gehrke L, Science. 2004 Dec 17;306(5704):2108-11. PMID:15604410 Page seeded by OCA on Sat May 3 15:17:56 2008

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