1xox
From Proteopedia
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'''SOLUTION STRUCTURE OF HUMAN SURVIVIN''' | '''SOLUTION STRUCTURE OF HUMAN SURVIVIN''' | ||
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[[Category: Olejniczak, E T.]] | [[Category: Olejniczak, E T.]] | ||
[[Category: Sun, C.]] | [[Category: Sun, C.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:18:49 2008'' | |
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Revision as of 12:18, 3 May 2008
SOLUTION STRUCTURE OF HUMAN SURVIVIN
Overview
NMR studies of the antiapoptotic protein survivin have been used to determine the homodimer interface of the protein in solution and to identify residues of the protein that interact with Smac/Diablo. In solution, survivin(1-120) forms a bow-tie-shaped dimer whose interface is composed of its N-terminal residues as well as residues connecting its BIR domain to the C-terminal alpha helix. The solution structure resolves the controversy regarding the two possible dimer interfaces for survivin observed in X-ray crystal structures. The structural basis for the interaction between survivin and Smac/Diablo was also investigated. When Smac/Diablo or N-terminal Smac/Diablo peptide analogues are added to a solution of survivin, specific residues near alpha4 and beta3 are perturbed. NMR experiments indicate that the peptides bind across the third beta-strand of survivin in a manner similar to the way Smac/Diablo peptides bind to the BIR3 domain of X-linked IAP (XIAP).
About this Structure
1XOX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of human survivin and its binding interface with Smac/Diablo., Sun C, Nettesheim D, Liu Z, Olejniczak ET, Biochemistry. 2005 Jan 11;44(1):11-7. PMID:15628841 Page seeded by OCA on Sat May 3 15:18:49 2008
