1xqj
From Proteopedia
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'''3.10 A Crystal structure of maspin, space group I 4 2 2''' | '''3.10 A Crystal structure of maspin, space group I 4 2 2''' | ||
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[[Category: Gettins, P G.]] | [[Category: Gettins, P G.]] | ||
[[Category: Volz, K.]] | [[Category: Volz, K.]] | ||
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| - | [[Category: | + | [[Category: Tumor suppression]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:22:28 2008'' | |
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Revision as of 12:22, 3 May 2008
3.10 A Crystal structure of maspin, space group I 4 2 2
Overview
Maspin, a member of the serpin superfamily, has tumor suppressing activity against breast and prostate cancer. Maspin inhibits tumor growth by blocking cell invasion, and its reactive center loop (RCL) is thought to mediate this activity. To understand this function on the molecular level, we have solved the three-dimensional structure of Maspin to 3.1 A resolution. The molecular structure shows the characteristic features of the serpin fold, but the RCL of Maspin is unique in length, composition, and placement. Although the RCL of Maspin is accessible and cleavable by some proteinases, it functions in the uncleaved, constrained conformation observed here. These structural results will contribute to our understanding of the mechanism by which Maspin suppresses tumors.
About this Structure
1XQJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human maspin, a serpin with antitumor properties: reactive center loop of maspin is exposed but constrained., Al-Ayyoubi M, Gettins PG, Volz K, J Biol Chem. 2004 Dec 31;279(53):55540-4. Epub 2004 Oct 22. PMID:15501821 Page seeded by OCA on Sat May 3 15:22:28 2008
