1xs7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1xs7.gif|left|200px]]
[[Image:1xs7.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1xs7 |SIZE=350|CAPTION= <scene name='initialview01'>1xs7</scene>, resolution 2.8&Aring;
+
The line below this paragraph, containing "STRUCTURE_1xs7", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MMI:N-[(4S,5S,7R)-8-({(S)-1-[(BENZYLAMINO)OXOMETHYL]-2-METHYLPROPYL}AMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXO-OCT-4-YL]-(4S,7S)-4-ISOPROPYL-2,5,9-TRIOXO-1-OXA-3,6,10-TRIAZACYCLOHEXADECANE-7-CARBOXAMIDE'>MMI</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= BACE1, BACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1xs7| PDB=1xs7 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xs7 OCA], [http://www.ebi.ac.uk/pdbsum/1xs7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xs7 RCSB]</span>
+
-
}}
+
'''Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).'''
'''Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).'''
Line 35: Line 32:
[[Category: Weerasena, V.]]
[[Category: Weerasena, V.]]
[[Category: Xu, X.]]
[[Category: Xu, X.]]
-
[[Category: acid protease]]
+
[[Category: Acid protease]]
-
[[Category: alzheimer's disease]]
+
[[Category: Alzheimer's disease]]
-
[[Category: asp2]]
+
[[Category: Asp2]]
-
[[Category: aspartic protease]]
+
[[Category: Aspartic protease]]
-
[[Category: bace]]
+
[[Category: Bace]]
-
[[Category: beta secretase]]
+
[[Category: Beta secretase]]
-
[[Category: crystallography]]
+
[[Category: Crystallography]]
-
[[Category: drug design]]
+
[[Category: Drug design]]
-
[[Category: memapsin2]]
+
[[Category: Memapsin2]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:26:46 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:53:57 2008''
+

Revision as of 12:26, 3 May 2008

Image:1xs7.gif

Template:STRUCTURE 1xs7

Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).


Overview

A series of novel macrocyclic amide-urethanes was designed and synthesized based upon the X-ray crystal structure of our lead inhibitor (1, OM99-2 with eight residues) bound to memapsin 2. Ring size and substituent effects have been investigated. Cycloamide-urethanes containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against human brain memapsin 2 (beta-secretase).

About this Structure

1XS7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase)., Ghosh AK, Devasamudram T, Hong L, DeZutter C, Xu X, Weerasena V, Koelsch G, Bilcer G, Tang J, Bioorg Med Chem Lett. 2005 Jan 3;15(1):15-20. PMID:15582402 Page seeded by OCA on Sat May 3 15:26:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xs7"
Personal tools