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1xtn

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[[Image:1xtn.gif|left|200px]]
[[Image:1xtn.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1xtn |SIZE=350|CAPTION= <scene name='initialview01'>1xtn</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1xtn", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Sgkl, Cisk, Sgk3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_1xtn| PDB=1xtn | SCENE= }}
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|RELATEDENTRY=[[1xte|1XTE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xtn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xtn OCA], [http://www.ebi.ac.uk/pdbsum/1xtn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xtn RCSB]</span>
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}}
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'''crystal structure of CISK-PX domain with sulfates'''
'''crystal structure of CISK-PX domain with sulfates'''
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[[Category: Xu, W.]]
[[Category: Xu, W.]]
[[Category: Zhang, R.]]
[[Category: Zhang, R.]]
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[[Category: cisk]]
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[[Category: Cisk]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: px domain]]
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[[Category: Px domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:29:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:54:28 2008''
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Revision as of 12:29, 3 May 2008

Image:1xtn.gif

Template:STRUCTURE 1xtn

crystal structure of CISK-PX domain with sulfates


Overview

The cytokine-independent survival kinase (CISK) in the serum and glucocorticoid-regulated kinase family plays an important role in mediating cell growth and survival. N-terminal to its catalytic kinase domain, CISK contains a phox homology (PX) domain, a phosphoinositide-binding motif that directs the membrane localization of CISK and regulates CISK activity. We have determined the crystal structures of the mouse CISK-PX domain to unravel the structural basis of membrane targeting of CISK. In addition to the specific interactions conferred by the phosphoinositide-binding pocket, the structure suggests that a hydrophobic loop region and a hydrophilic beta-turn contribute to the interactions with the membrane. Furthermore, biochemical studies reveal that CISK-PX dimerizes in the presence of the linker between the PX domain and kinase domain, suggesting a multivalent mechanism in membrane localization of CISK.

About this Structure

1XTN is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX)., Xing Y, Liu D, Zhang R, Joachimiak A, Songyang Z, Xu W, J Biol Chem. 2004 Jul 16;279(29):30662-9. Epub 2004 May 4. PMID:15126499 Page seeded by OCA on Sat May 3 15:29:46 2008

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