1xud

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[[Image:1xud.jpg|left|200px]]
[[Image:1xud.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1xud |SIZE=350|CAPTION= <scene name='initialview01'>1xud</scene>, resolution 1.800&Aring;
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The line below this paragraph, containing "STRUCTURE_1xud", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PB4:N,N&#39;-BIS(4-FLUORO-3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE'>PB4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1xud| PDB=1xud | SCENE= }}
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|RELATEDENTRY=[[1xuc|1XUC]], [[1xur|1XUR]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xud OCA], [http://www.ebi.ac.uk/pdbsum/1xud PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xud RCSB]</span>
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}}
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'''Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor'''
'''Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor'''
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[[Category: Engel, C K.]]
[[Category: Engel, C K.]]
[[Category: Wendt, K U.]]
[[Category: Wendt, K U.]]
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[[Category: matrix metalloproteinase]]
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[[Category: Matrix metalloproteinase]]
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[[Category: non-zinc binding inhibitor]]
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[[Category: Non-zinc binding inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:31:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:54:46 2008''
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Revision as of 12:31, 3 May 2008

Image:1xud.jpg

Template:STRUCTURE 1xud

Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor


Overview

The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. present novel compounds, completely selective for MMP-13, with a unique binding mode.

About this Structure

1XUD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:15734640 Page seeded by OCA on Sat May 3 15:31:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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