1xuq

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[[Image:1xuq.gif|left|200px]]
[[Image:1xuq.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1xuq |SIZE=350|CAPTION= <scene name='initialview01'>1xuq</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1xuq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= sodA1, sodA-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])
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-->
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|DOMAIN=
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{{STRUCTURE_1xuq| PDB=1xuq | SCENE= }}
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|RELATEDENTRY=[[1xre|1XRE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xuq OCA], [http://www.ebi.ac.uk/pdbsum/1xuq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xuq RCSB]</span>
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}}
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'''Crystal Structure of SodA-1 (BA4499) from Bacillus anthracis at 1.8A Resolution.'''
'''Crystal Structure of SodA-1 (BA4499) from Bacillus anthracis at 1.8A Resolution.'''
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[[Category: Wilkinson, A J.]]
[[Category: Wilkinson, A J.]]
[[Category: Wilson, K S.]]
[[Category: Wilson, K S.]]
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[[Category: ba4499]]
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[[Category: Ba4499]]
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[[Category: bacillus anthracis]]
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[[Category: Bacillus anthracis]]
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[[Category: soda-1]]
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[[Category: Soda-1]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: superoxide dismutase]]
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[[Category: Superoxide dismutase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:31:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:54:57 2008''
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Revision as of 12:31, 3 May 2008

Image:1xuq.gif

Template:STRUCTURE 1xuq

Crystal Structure of SodA-1 (BA4499) from Bacillus anthracis at 1.8A Resolution.


Overview

The BA4499 and BA5696 genes of Bacillus anthracis encode proteins homologous to manganese superoxide dismutase, suggesting that this organism has an expanded repertoire of antioxidant proteins. Differences in metal specificity and quaternary structure between the dismutases of prokaryotes and higher eukaryotes may be exploited in the development of therapeutic antibacterial compounds. Here, the crystal structure of two Mn superoxide dismutases from B. anthracis solved to high resolution are reported. Comparison of their structures reveals that a highly conserved residue near the active centre is substituted in one of the proteins and that this is a characteristic feature of superoxide dismutases from the B. cereus/B. anthracis/B. thuringiensis group of organisms.

About this Structure

1XUQ is a Single protein structure of sequence from Bacillus anthracis. Full crystallographic information is available from OCA.

Reference

Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre., Boucher IW, Kalliomaa AK, Levdikov VM, Blagova EV, Fogg MJ, Brannigan JA, Wilson KS, Wilkinson AJ, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 1;61(Pt, 7):621-4. Epub 2005 Jun 15. PMID:16511113 Page seeded by OCA on Sat May 3 15:31:53 2008

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