2b4c

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Revision as of 18:51, 12 November 2007

Image:2b4c.gif

2b4c, resolution 3.30Å

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Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody

Overview

The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is, immunodominant and contains features essential for coreceptor binding. We, determined the structure of V3 in the context of an HIV-1 gp120 core, complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom, resolution. Binding of gp120 to cell-surface CD4 would position V3 so that, its coreceptor-binding tip protrudes 30 angstroms from the core toward the, target cell membrane. The extended nature and antibody accessibility of V3, explain its immunodominance. Together, the results provide a structural, rationale for the role of V3 in HIV entry and neutralization.

About this Structure

2B4C is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1 with NAG, NDG, XYL and SO4 as ligands. Full crystallographic information is available from OCA.

Reference

Structure of a V3-containing HIV-1 gp120 core., Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, Wyatt R, Kwong PD, Science. 2005 Nov 11;310(5750):1025-8. PMID:16284180

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