2b4n

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(New page: 200px<br /> <applet load="2b4n" size="450" color="white" frame="true" align="right" spinBox="true" caption="2b4n" /> '''Solution Structure of Glucose-Dependent Ins...)
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Revision as of 18:52, 12 November 2007

Image:2b4n.gif

2b4n

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Solution Structure of Glucose-Dependent Insulinotropic Polypeptide

Contents

Overview

Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone, that stimulates the secretion of insulin after ingestion of food. GIP also, promotes the synthesis of fatty acids in adipose tissue. Therefore, it is, not surprising that numerous literature reports have shown that GIP is, linked to diabetes and obesity-related diseases. In this study, we present, the solution structure of GIP in water determined by NMR spectroscopy. The, calculated structure is characterized by the presence of an alpha-helical, motif between residues Ser(11) and Gln(29). The helical conformation of, GIP is further supported by CD spectroscopic studies. Six, GIP-(1-42)Ala(1-7) analogues were synthesized by replacing individual, N-terminal residues with alanine. Alanine scan studies of these N-terminal, residues showed that the GIP-(1-42)Ala(6) was the only analogue to show, insulin-secreting activity similar to that of the native GIP. However, when compared with glucose, its insulinotropic ability was reduced. For, the first time, these NMR and modeling results contribute to the, understanding of the structural requirements for the biological activity, of GIP.

Disease

Known diseases associated with this structure: Pituitary ACTH-secreting adenoma OMIM:[139360], Ventricular tachycardia, idiopathic OMIM:[139360]

About this Structure

2B4N is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water., Alana I, Parker JC, Gault VA, Flatt PR, O'Harte FP, Malthouse JP, Hewage CM, J Biol Chem. 2006 Jun 16;281(24):16370-6. Epub 2006 Apr 18. PMID:16621806

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