1y02
From Proteopedia
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'''Crystal Structure of a FYVE-type domain from caspase regulator CARP2''' | '''Crystal Structure of a FYVE-type domain from caspase regulator CARP2''' | ||
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[[Category: Shiozaki, E N.]] | [[Category: Shiozaki, E N.]] | ||
[[Category: Tibbetts, M D.]] | [[Category: Tibbetts, M D.]] | ||
| - | [[Category: | + | [[Category: Carp2]] |
| - | [[Category: | + | [[Category: Caspase regulation]] |
| - | [[Category: | + | [[Category: Fyve]] |
| - | [[Category: | + | [[Category: Phosphoinositide binding]] |
| - | [[Category: | + | [[Category: Zinc-binding module]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:43:13 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 12:43, 3 May 2008
Crystal Structure of a FYVE-type domain from caspase regulator CARP2
Overview
The caspase-associated ring proteins (CARP1 and CARP2) are distinguished from other caspase regulators by the presence of a FYVE-type zinc finger domain. FYVE-type domains are divided into two known classes: FYVE domains that specifically bind to phosphatidylinositol 3-phosphate in lipid bilayers and FYVE-related domains of undetermined function. Here, we report the crystal structure of the N-terminal region of CARP2 (44-139) including the FYVE-type domain and its associated helical bundle at 1.7 A resolution. The structure reveals a cramped phosphoinositide binding pocket and a blunted membrane insertion loop. These structural features indicate that the domain is not optimized to bind to phosphoinositides or insert into lipid bilayers. The CARP2 FYVE-like domain thus defines a third subfamily of FYVE-type domains that are functionally and structurally distinct. Structural analyses provide insights into the possible function of this unique subfamily of FYVE-type domains.
About this Structure
1Y02 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2., Tibbetts MD, Shiozaki EN, Gu L, McDonald ER 3rd, El-Deiry WS, Shi Y, Structure. 2004 Dec;12(12):2257-63. PMID:15576038 Page seeded by OCA on Sat May 3 15:43:13 2008
