1y0h
From Proteopedia
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'''Structure of Rv0793 from Mycobacterium tuberculosis''' | '''Structure of Rv0793 from Mycobacterium tuberculosis''' | ||
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[[Category: TBSGC, TB Structural Genomics Consortium.]] | [[Category: TBSGC, TB Structural Genomics Consortium.]] | ||
[[Category: Wang, M.]] | [[Category: Wang, M.]] | ||
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Revision as of 12:44, 3 May 2008
Structure of Rv0793 from Mycobacterium tuberculosis
Overview
Mycobacterium tuberculosis infects millions worldwide. The Structural Genomics Consortium for M. tuberculosis has targeted all genes from this bacterium in hopes of discovering and developing new therapeutic agents. Open reading frame Rv0793 from M. tuberculosis was annotated with an unknown function. The 3-dimensional structure of Rv0793 has been solved to 1.6 A resolution. Its structure is very similar to that of Streptomyces coelicolor ActVA-Orf6, a monooxygenase that participates in tailoring of polyketide antibiotics in the absence of a cofactor. It is also similar to the recently solved structure of YgiN, a quinol monooxygenase from Escherichia coli. In addition, the structure of Rv0793 is similar to several structures of other proteins with unknown function. These latter structures have been determined recently as a result of structural genomic projects for various bacterial species. In M. tuberculosis, Rv0793 and its homologs may represent a class of monooygenases acting as reactive oxygen species scavengers that are essential for evading host defenses. Since the most prevalent mode of attack by the host defense on M. tuberculosis is by reactive oxygen species and reactive nitrogen species, Rv0793 may provide a novel target to combat infection by M. tuberculosis.
About this Structure
1Y0H is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis., Lemieux MJ, Ference C, Cherney MM, Wang M, Garen C, James MN, J Struct Funct Genomics. 2005 Dec;6(4):245-57. Epub 2006 Feb 22. PMID:16496224 Page seeded by OCA on Sat May 3 15:44:01 2008
Categories: Mycobacterium tuberculosis | Single protein | Cherney, M M. | Ference, C. | Garen, C. | James, M N. | Lemieux, M J. | TBSGC, TB Structural Genomics Consortium. | Wang, M. | Alpha+beta sandwich with antiparallel beta-sheet | Ferredoxin-like fold | Protein structure initiative | Psi | Structural genomic | Tb structural genomics consortium | Tbsgc
