1y10

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[[Image:1y10.gif|left|200px]]
[[Image:1y10.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1y10 |SIZE=350|CAPTION= <scene name='initialview01'>1y10</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1y10", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Rv1264 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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-->
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|DOMAIN=
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{{STRUCTURE_1y10| PDB=1y10 | SCENE= }}
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|RELATEDENTRY=[[1y11|1Y11]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y10 OCA], [http://www.ebi.ac.uk/pdbsum/1y10 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1y10 RCSB]</span>
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}}
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'''Mycobacterial adenylyl cyclase Rv1264, holoenzyme, inhibited state'''
'''Mycobacterial adenylyl cyclase Rv1264, holoenzyme, inhibited state'''
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[[Category: Sinning, I.]]
[[Category: Sinning, I.]]
[[Category: Tews, I.]]
[[Category: Tews, I.]]
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[[Category: adenylyl cyclase fold]]
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[[Category: Adenylyl cyclase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:45:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:57:32 2008''
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Revision as of 12:45, 3 May 2008

Image:1y10.gif

Template:STRUCTURE 1y10

Mycobacterial adenylyl cyclase Rv1264, holoenzyme, inhibited state


Overview

Class III adenylyl cyclases contain catalytic and regulatory domains, yet structural insight into their interactions is missing. We show that the mycobacterial adenylyl cyclase Rv1264 is rendered a pH sensor by its N-terminal domain. In the structure of the inhibited state, catalytic and regulatory domains share a large interface involving catalytic residues. In the structure of the active state, the two catalytic domains rotate by 55 degrees to form two catalytic sites at their interface. Two alpha helices serve as molecular switches. Mutagenesis is consistent with a regulatory role of the structural transition, and we suggest that the transition is regulated by pH.

About this Structure

1Y10 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme., Tews I, Findeisen F, Sinning I, Schultz A, Schultz JE, Linder JU, Science. 2005 May 13;308(5724):1020-3. PMID:15890882 Page seeded by OCA on Sat May 3 15:45:13 2008

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