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1y54

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[[Image:1y54.gif|left|200px]]
[[Image:1y54.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1y54 |SIZE=350|CAPTION= <scene name='initialview01'>1y54</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1y54", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FDT:(7R)-6-FORMYL-7-(1-METHYL-1H-1,2,3-TRIAZOL-4-YL)-4,7-DIHYDRO-1,4-THIAZEPINE-3-CARBOXYLIC+ACID'>FDT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1y54| PDB=1y54 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y54 OCA], [http://www.ebi.ac.uk/pdbsum/1y54 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1y54 RCSB]</span>
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}}
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'''Crystal structure of the native class C beta-lactamase from Enterobacter cloacae 908R complexed with BRL42715'''
'''Crystal structure of the native class C beta-lactamase from Enterobacter cloacae 908R complexed with BRL42715'''
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[[Category: Michaux, C.]]
[[Category: Michaux, C.]]
[[Category: Wouters, J.]]
[[Category: Wouters, J.]]
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[[Category: class c beta-lactamase]]
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[[Category: Class c beta-lactamase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:53:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:58:57 2008''
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Revision as of 12:53, 3 May 2008

Image:1y54.gif

Template:STRUCTURE 1y54

Crystal structure of the native class C beta-lactamase from Enterobacter cloacae 908R complexed with BRL42715


Overview

BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, is an active-site-directed inactivator of bacterial beta-lactamases. The crystal structure of Enterobacter cloacae 908R class C beta-lactamase in complex with BRL 42715, docking, and energy minimization studies explain stereoselectivity of the binding of C6-(heterocyclic methylene)penems against class C beta-lactamase.

About this Structure

1Y54 is a Single protein structure of sequence from Enterobacter cloacae. Full crystallographic information is available from OCA.

Reference

Crystal structure of BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, in complex with Enterobacter cloacae 908R beta-lactamase: evidence for a stereoselective mechanism from docking studies., Michaux C, Charlier P, Frere JM, Wouters J, J Am Chem Soc. 2005 Mar 16;127(10):3262-3. PMID:15755127 Page seeded by OCA on Sat May 3 15:53:23 2008

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