1y6e

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[[Image:1y6e.gif|left|200px]]
[[Image:1y6e.gif|left|200px]]
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{{Structure
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|PDB= 1y6e |SIZE=350|CAPTION= <scene name='initialview01'>1y6e</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1y6e", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span>
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{{STRUCTURE_1y6e| PDB=1y6e | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6e OCA], [http://www.ebi.ac.uk/pdbsum/1y6e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1y6e RCSB]</span>
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'''Orthorhombic glutathione S-transferase of Schistosoma japonicum'''
'''Orthorhombic glutathione S-transferase of Schistosoma japonicum'''
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[[Category: Rufer, A C.]]
[[Category: Rufer, A C.]]
[[Category: Thiebach, L.]]
[[Category: Thiebach, L.]]
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[[Category: dimer]]
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[[Category: Dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:55:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:59:22 2008''
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Revision as of 12:55, 3 May 2008

Image:1y6e.gif

Template:STRUCTURE 1y6e

Orthorhombic glutathione S-transferase of Schistosoma japonicum


Overview

The crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum (SjGST) was determined at 3 A resolution in the new space group P2(1)2(1)2(1). The structure of orthorhombic SjGST reveals unique features of the ligand-binding site and dimer interface when compared with previously reported structures. SjGST is recognized as the major detoxification enzyme of S. japonicum, a pathogenic helminth causing schistosomiasis. As resistance against the established inhibitor of SjGST, praziquantel, has been reported these results might prove to be valuable for the development of novel drugs.

About this Structure

1Y6E is a Single protein structure of sequence from Schistosoma japonicum. Full crystallographic information is available from OCA.

Reference

X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site., Rufer AC, Thiebach L, Baer K, Klein HW, Hennig M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):263-5. Epub 2005 Feb 24. PMID:16511012 Page seeded by OCA on Sat May 3 15:55:29 2008

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