1y8b
From Proteopedia
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'''Solution NMR-Derived Global Fold of Malate Synthase G from E.coli''' | '''Solution NMR-Derived Global Fold of Malate Synthase G from E.coli''' | ||
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[[Category: Tugarinov, V.]] | [[Category: Tugarinov, V.]] | ||
[[Category: 82 kda enzyme]] | [[Category: 82 kda enzyme]] | ||
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| - | [[Category: | + | [[Category: Nmr global fold]] |
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Revision as of 12:59, 3 May 2008
Solution NMR-Derived Global Fold of Malate Synthase G from E.coli
Overview
The size of proteins that can be studied by solution NMR spectroscopy has increased significantly because of recent developments in methodology. Important experiments include those that make use of approaches that increase the lifetimes of NMR signals or that define the orientation of internuclear bond vectors with respect to a common molecular frame. The advances in NMR techniques are strongly coupled to isotope labeling methods that increase sensitivity and reduce the complexity of NMR spectra. We show that these developments can be exploited in structural studies of high-molecular-weight, single-polypeptide proteins, and we present the solution global fold of the monomeric 723-residue (82-kDa) enzyme malate synthase G from Escherichia coli, which has been extensively characterized by NMR in the past several years.
About this Structure
1Y8B is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Solution NMR-derived global fold of a monomeric 82-kDa enzyme., Tugarinov V, Choy WY, Orekhov VY, Kay LE, Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):622-7. Epub 2005 Jan 6. PMID:15637152 Page seeded by OCA on Sat May 3 15:59:49 2008
