1y9r
From Proteopedia
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'''Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone and harboring the S810L mutation responsible for a severe form of hypertension''' | '''Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone and harboring the S810L mutation responsible for a severe form of hypertension''' | ||
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[[Category: Rafestin-Oblin, M E.]] | [[Category: Rafestin-Oblin, M E.]] | ||
[[Category: Rochel, M.]] | [[Category: Rochel, M.]] | ||
| - | [[Category: | + | [[Category: Activating mutation]] |
| - | [[Category: | + | [[Category: Hypertension]] |
| - | [[Category: | + | [[Category: Mineralocorticoid receptor]] |
| - | [[Category: | + | [[Category: Nuclear recept]] |
| - | [[Category: | + | [[Category: Steroid receptor]] |
| - | [[Category: | + | [[Category: Transcription regulation]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:03:05 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:03, 3 May 2008
Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone and harboring the S810L mutation responsible for a severe form of hypertension
Overview
The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.
About this Structure
1Y9R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension., Fagart J, Huyet J, Pinon GM, Rochel M, Mayer C, Rafestin-Oblin ME, Nat Struct Mol Biol. 2005 Jun;12(6):554-5. Epub 2005 May 22. PMID:15908963 Page seeded by OCA on Sat May 3 16:03:05 2008
