1ycd

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[[Image:1ycd.gif|left|200px]]
[[Image:1ycd.gif|left|200px]]
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{{Structure
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|PDB= 1ycd |SIZE=350|CAPTION= <scene name='initialview01'>1ycd</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1ycd", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=LI5:2-HYDROXY-4,5-DIOXOHEPTYL+HYDROGEN+PHOSPHONATE'>LI5</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= YHR049w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=
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{{STRUCTURE_1ycd| PDB=1ycd | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ycd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ycd OCA], [http://www.ebi.ac.uk/pdbsum/1ycd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ycd RCSB]</span>
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'''Crystal structure of yeast FSH1/YHR049W, a member of the serine hydrolase family'''
'''Crystal structure of yeast FSH1/YHR049W, a member of the serine hydrolase family'''
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[[Category: Tilbeurgh, H van.]]
[[Category: Tilbeurgh, H van.]]
[[Category: YSG, Paris-Sud Yeast Structural Genomics.]]
[[Category: YSG, Paris-Sud Yeast Structural Genomics.]]
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[[Category: esterase]]
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[[Category: Esterase]]
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[[Category: lipase]]
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[[Category: Lipase]]
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[[Category: paris-sud yeast structural genomic]]
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[[Category: Paris-sud yeast structural genomic]]
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[[Category: s. cerevisiae]]
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[[Category: S. cerevisiae]]
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[[Category: serine hydrolase]]
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[[Category: Serine hydrolase]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: ysg]]
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[[Category: Ysg]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:08:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:02:39 2008''
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Revision as of 13:08, 3 May 2008

Image:1ycd.gif

Template:STRUCTURE 1ycd

Crystal structure of yeast FSH1/YHR049W, a member of the serine hydrolase family


Overview

Yhr049w/FSH1 was recently identified in a combined computational and experimental proteomics analysis for the detection of active serine hydrolases in yeast. This analysis suggested that FSH1 might be a serine-type hydrolase belonging to the broad functional alphabeta-hydrolase superfamily. In order to get insight into the molecular function of this gene, it was targeted in our yeast structural genomics project. The crystal structure of the protein confirms that it contains a Ser/His/Asp catalytic triad that is part of a minimal alpha/beta-hydrolase fold. The architecture of the putative active site and analogies with other protein structures suggest that FSH1 may be an esterase. This finding was further strengthened by the unexpected presence of a compound covalently bound to the catalytic serine in the active site. Apparently, the enzyme was trapped with a reactive compound during the purification process.

About this Structure

1YCD is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of yeast YHR049W/FSH1, a member of the serine hydrolase family., Quevillon-Cheruel S, Leulliot N, Graille M, Hervouet N, Coste F, Benedetti H, Zelwer C, Janin J, Van Tilbeurgh H, Protein Sci. 2005 May;14(5):1350-6. Epub 2005 Mar 31. PMID:15802654 Page seeded by OCA on Sat May 3 16:08:55 2008

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