1ydg

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[[Image:1ydg.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1ydg", creates the "Structure Box" on the page.
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|GENE= DRA0214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1299 Deinococcus radiodurans])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK03767 PRK03767]</span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ydg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ydg OCA], [http://www.ebi.ac.uk/pdbsum/1ydg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ydg RCSB]</span>
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'''Crystal Structure of Trp repressor binding protein WrbA'''
'''Crystal Structure of Trp repressor binding protein WrbA'''
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Shapiro, L.]]
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[[Category: new york structural genomix research consortium]]
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[[Category: New york structural genomix research consortium]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: tetramer]]
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Revision as of 13:11, 3 May 2008

Image:1ydg.gif

Template:STRUCTURE 1ydg

Crystal Structure of Trp repressor binding protein WrbA


Overview

The tryptophan repressor binding protein WrbA binds to the tryptophan repressor protein TrpR. Although the biological role of WrbA remains unclear, it has been proposed to function in enhancing the stability of TrpR-DNA complexes. Sequence database analysis has identified WrbA as a founding member of a flavodoxin-like family of proteins. Here we present crystal structures of WrbA from Deinococcus radiodurans and Pseudomonas aeruginosa and their complexes with flavin mononucleotide. The protomer structure is similar to that of previously determined long-chain flavodoxins; however, each contains a conserved inserted region unique to the WrbA family. Interestingly, each WrbA protein forms a homotetramer with 222 symmetry, unique among flavodoxin-like proteins, in which each protomer binds one flavin mononucleotide cofactor molecule.

About this Structure

1YDG is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide., Gorman J, Shapiro L, Protein Sci. 2005 Dec;14(12):3004-12. PMID:16322580 Page seeded by OCA on Sat May 3 16:11:09 2008

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